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KMID : 0624620120450100545
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BMB Reports
2012 Volume.45 No. 10 p.545 ~ p.553
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Body fluid identification in forensics
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An Ja-Hyun
Shin Kyoung-Jin
Yang Woo-Ick
Lee Hwan-Young
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Abstract
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Determination of the type and origin of the body fluids found at a crime scene can give important insights into crime scene reconstruction by supporting a link between sample donors and actual criminal acts. For more than a century, numerous types of body fluid identification methods have been developed, such as chemical tests, immunological tests, protein catalytic activity tests, spectroscopic methods and microscopy. However, these conventional body fluid identificationmethods are mostly presumptive, and are carried out for only one body fluid at a time. Therefore, the use of a molecular genetics-based approach using RNA profiling or DNA methylation detection has been recently proposed to supplant conventional body fluid identification methods. Several RNA markers and tDMRs (tissue-specific differentially methylated regions) which are specific to forensically relevant body fluids have been identified, and their specificities and sensitivities have been tested using various samples. In this review, we provide an overview of the present knowledge and the most recent developments in forensic body fluid identification and discuss its possible practical application to forensic casework.
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KEYWORD
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Alternate light source, Body fluid identification, Catalytic test, Chemical test, DNA methylation, Forensic, Immunological test, miRNA, mRNA
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